| Item type |
[ELS]紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2017-09-04 |
| タイトル |
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|
タイトル |
日本人学童におけるβ_3アドレナリン受容体遺伝子の変異と肥満との関連について |
| タイトル |
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|
タイトル |
Association of Trp64Arg mutation of the β_3-adrenergic receptor gene with obesity in school-age Japanese children |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
β_3-adrenergic receptor gene |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
obesity |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
school-children |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
blood pressure |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| ID登録 |
|
|
ID登録 |
10.20843/00000147 |
|
ID登録タイプ |
JaLC |
| 雑誌書誌ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN10480238 |
| ページ属性 |
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内容記述タイプ |
Other |
|
内容記述 |
P |
| 著者 |
平野, 千秋
遠藤, 数江
柳, 久子
戸村, 成男
Hirano, Chiaki
Endoh, Kazue
YANAGI, Hisako
TOMURA, Shigeo
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| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Institute of Community Services, Tsukuba International University|Institute of Community Medicine, University of Tsukuba|Institute of Community Medicine, University of Tsukuba|Institute of Community Medicine, University of Tsukuba |
| 抄録(英) |
|
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内容記述タイプ |
Other |
|
内容記述 |
The β_3-adrenergic system plays an important role in regulating the energy balance through thermogenesis and lipolysis in white and brown adipose tissues. Recently, a possible pathogenic mutation in human β_3-AR genes (codon64 TGGTrp→CGGArg; Trp64Arg) has been reported to be associated with obesity and insulin resistance among several population. We investigated the Trp64Arg mutation of the β_3-AR gene in 450 school-age Japanese children. One group of 225 children (121 boys and 104 girls) with a mean age of 11.7 and an obesity index greater more than twenty percent constituted the obese group. Two hundred and twenty-five non-obese children were matched to each obese subject for gender and for age to the control group. The allele frequency of this mutation in the obese group was significantly higher than that in the control group (0.24 versus 0.12, p<0.01). The prevalence of this mutation was also significantly more increased in the obese group than in the control group (44.0% versus 24.0%, x^2=11.3, p<0.001). Significantly higher blood pressure was observed in obese subjects with this mutation than in obese subjects without mutation after correction for gender, age, and body weight (systolic; 112.3±11.7mmHg versus 108.2±11.8mmHg, p<0.01 and diastolic; 63.2±8.4mmHg versus 60.2±8.3mmHg, p<0.001). In each group, there was no significant differences in body weight, obesity index, body mass index, and serum lipid concentrations between β_3-AR genotypes. Our results suggest that the Trp64Arg mutation of the β_3-AR gene is associated with obesity and even some physiological systems, such as blood pressure, in school-age Japanese children. |
| 書誌情報 |
研究紀要
en : Bulletin of Tsukuba International University
巻 9,
p. 33-41,
発行日 2003-03-25
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| 表示順 |
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内容記述タイプ |
Other |
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内容記述 |
8 |
| アクセション番号 |
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内容記述タイプ |
Other |
|
内容記述 |
KJ00004011226 |
| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13412224 |
KJ00004011226.pdf (539.6 kB)
